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Ayvakit

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Ayvakit

Supplied with complete CDSCO-approved import and customs documentation, including Form 12A & 12B, CDEC, GST Bill of Entry, Commercial Invoice, and Packing List.

Medicine Name: Ayvakit
Generic Name (API): Avapritinib
Dosage Form & Strength: 300 mg, 100 mg
Route: Oral
Drug Class: Tyrosine kinase inhibitor (KIT/PDGFRA inhibitor)

Manufacturer / Innovator:

China

Regulatory Approval:

  • US FDA
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  • Temperature-Controlled Logistics for Safe and Timely Delivery

    Temperature-controlled logistics ensuring safe, reliable, and timely medicine delivery.

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What Is Ayvakit Used For?

Ayvakit (avapritinib) is a tyrosine kinase inhibitor that targets KIT and PDGFRA mutations. It is indicated for the treatment of adults with:

  • Unresectable or metastatic gastrointestinal stromal tumor (GIST) harboring a PDGFRA exon 18 mutation, including PDGFRA D842V mutations
  • Advanced systemic mastocytosis (AdvSM), including aggressive systemic mastocytosis, systemic mastocytosis with an associated hematological neoplasm, and mast cell leukemia
  • Indolent systemic mastocytosis (ISM)

Ayvakit is not recommended in AdvSM or ISM patients with platelet counts below 50 × 10⁹/L. It is a prescription oncology medicine and must be used under the supervision of a qualified oncologist or hematologist, following confirmation of the relevant mutation.

Recommended Dosage

  • GIST: 300 mg orally once daily
  • Advanced systemic mastocytosis: 200 mg orally once daily
  • Indolent systemic mastocytosis: a lower dose, individualized by the treating physician

Continued until disease progression or unacceptable toxicity. This information is not a treatment plan. For personalized medical advice, consult your doctor and refer to the full prescribing information.

Ayvakit Warnings and Precautions

  • Intracranial hemorrhage: Serious, sometimes fatal, bleeding in the brain has been reported. Ayvakit should be permanently discontinued for any occurrence, regardless of severity.
  • Cognitive effects: Memory impairment, confusion, and disorientation have been reported in a substantial proportion of patients. Dose adjustment or discontinuation may be needed depending on severity.
  • Embryo-fetal toxicity: Ayvakit can cause fetal harm. Effective contraception is required during treatment.
  • Drug interactions: Strong or moderate CYP3A inhibitors should be avoided, particularly in ISM patients, as they can significantly increase Ayvakit levels.

How to Access Ayvakit in India: A 6-Step Process

Step 1 – Search & request your medicine: The patient or treating doctor submits a request with basic details to initiate the access process.

Step 2 – Verification & eligibility review: The team verifies availability and reviews eligibility against regulatory and clinical requirements to ensure a compliant pathway.

Step 3 – Receive quote & delivery timeline: A transparent quotation is shared, covering medicine cost, logistics, and a clear delivery timeline.

Step 4 – Regulatory approval process: Assistance is provided to secure the approvals and documentation required for legal cross-border access.

Step 5 – Temperature-controlled import & handling: The medicine is sourced and transported under strict GDP-compliant conditions to maintain product integrity.

Step 6 – Secure delivery: The medicine is delivered to the patient or treating hospital, with updates provided at each stage.

Note: From request to delivery, every step is designed to ensure your treatment reaches you safely, compliantly, and without unnecessary delays.

Documentation & Availability

What documents are required to import Ayvakit to India?

Ayvakit (avapritinib) tablets may be imported in the patient's name only, by patients or government hospitals, in line with India's import regulations for unapproved medicines. The following documentation is required:

  • A valid prescription from a qualified doctor
  • The patient's diagnostic reports, including confirmation of the relevant PDGFRA or KIT mutation
  • Patient ID proof (issued by the Government of India)

How is the order confirmed?

The order is confirmed only after receipt and verification of a valid prescription from the doctor and, if applicable, an import permit.

Is Ayvakit available in India?

Ayvakit (avapritinib tablets) is a prescription medicine that legally requires a doctor's prescription to be dispensed. As of current publicly available information, Ayvakit is not commercially marketed in India.

However, patients in India can legally access Ayvakit through the Named Patient Program (NPP) — an import provision that allows a medicine not yet registered in India to be imported in the name of a specific patient for their personal treatment, under a valid prescription.

Ayvakit received US FDA approval for GIST in 2020, with subsequent approvals for advanced and indolent systemic mastocytosis, ensuring full transparency throughout the process.

Ayvakit can be made available to patients, doctors, and hospitals across major cities in India, including Gurgaon, Delhi, Bangalore, Mumbai, Navi Mumbai, Thane, Hyderabad, Mysore, Kerala, Chennai, Coimbatore, Madurai, Kolkata, Ahmedabad, Surat, Vadodara, Pune, Nagpur, Nashik, Jaipur, Udaipur, Lucknow, Kanpur, Gorakhpur, Chandigarh, Mohali, Faridabad, Noida, Ghaziabad, Kochi, Trivandrum, Kozhikode, Thrissur, Kannur, Mangalore, Bhubaneswar, Patna, Ranchi, Raipur, Guwahati, Visakhapatnam, Vijayawada, Goa, Jammu, Srinagar, Dehradun, Bhopal, Indore, Ludhiana, Amritsar, and others — and can facilitate delivery to the patient's treating hospital. Orders are confirmed only after receipt of a valid doctor's prescription and an import permit, where applicable.

Sourcing & Delivery

NamedPatientProgram.com (NPP) can source Ayvakit from reliable global channels and facilitate supply to patients, doctors, and hospitals under applicable legal provisions. Ayvakit tablets should be stored at 20°C to 25°C, with excursions permitted between 15°C and 30°C, and are handled under temperature-controlled shipping conditions throughout transit. All prescriptions are dispensed and checked by registered pharmacists and dispatched from New Delhi, India, after legal requirements are fulfilled.

For Ayvakit cost in India and availability, contact NPP via WhatsApp at +91 98104 69557 | Toll-Free: 1800-1200-365 or email info@namedpatientprogram.com.

Availability of Ayvakit Across Major Cities in India

Patients across India can access Ayvakit through regulated import pathways, with delivery arranged to the treating hospital based on a valid oncologist's or hematologist's prescription.

Mumbai

A major oncology hub with institutions like Tata Memorial, Mumbai coordinates access to advanced GIST and mastocytosis therapies like Ayvakit for eligible patients.

Delhi

As part of the Delhi NCR region, the city has a strong concentration of cancer centers, making it a key location for accessing targeted GIST and mastocytosis treatments.

Bangalore

With a growing network of multispecialty oncology hospitals, Bangalore supports access to Ayvakit through structured import pathways guided by treating specialists.

Chennai

Home to several reputed cancer treatment centers, Chennai facilitates access to Ayvakit for patients with PDGFRA-mutated GIST or systemic mastocytosis.

Hyderabad

A growing hub for oncology care, Hyderabad supports coordinated access to Ayvakit for eligible patients under specialist supervision.

Kolkata

Eastern India's leading cancer centers in Kolkata coordinate Ayvakit access for patients with advanced GIST or mastocytosis.

Pune

With an expanding base of oncology clinics, Pune facilitates timely access to Ayvakit under prescription.

Ahmedabad

Gujarat's leading cancer hospitals support regulated access to Ayvakit for eligible patients.

Kochi

Kerala's healthcare network, including major cancer centers in Kochi, coordinates access to advanced targeted therapies like Ayvakit.

Chandigarh

Serving North India, Chandigarh's oncology centers facilitate access to Ayvakit for patients from Punjab, Haryana, and Himachal Pradesh.

Jaipur

Rajasthan's leading hospitals support patient access to Ayvakit through the Named Patient Program.

Lucknow

A key referral center for North India, Lucknow facilitates coordinated access to Ayvakit under oncologist care.

Bhubaneswar

Odisha's growing oncology sector supports patient access to Ayvakit.

Guwahati

As a referral hub for the North-East, Guwahati facilitates access to Ayvakit for patients across the region.

Access can also be coordinated for patients in other major Indian cities, subject to a valid prescription and regulatory requirements.

Written By:

Written By: Nitin Goswami, Senior Medical Content Writer
Last Updated: 08 September 2026
Sources: FDA • CDSCO

Medically Reviewed By:

Medically Reviewed By: Shilpi Banerjee, Registered Pharmacist (M.Pharm)
Last Updated: 08 September 2026

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